Announcement PDF ASX Announcement – 8 June 2026 Resonance Health Ltd ABN: 96 006 762 492 141 Burswood Road, Burswood, WA 6100, AUSTRALIA Postal: PO Box 108, Victoria Park, WA 6979, AUSTRALIA www.resonancehealth.com T + 61 8 9286 5300 info@resonancehealth.com MRI LIVER FIBROSIS DEVICE PROGRESS & FY26 PORTFOLIO UPDATE WEBINAR Resonance Health Limited (Resonance or Company) (ASX: RHT) has today released an ‘MRI Liver Fibrosis Device Progress & FY26 Portfolio Update’ investor presentation which is enclosed with this announcement. Investors are invited to join a live webinar and Q&A hosted by Andrew Harrison, MD & CEO, and Dr Wenjie Pang, Chief Scientific Officer, on Tuesday 9th June 2026 at 10:00 a.m. Australian Western (Perth) Time (AWST). You can attend the webinar via this link: https://investors.resonancehealth.com/webinars/Ve9GDP-investor-webinar-9-june-liver- fibrosis-device-progress-key-milestones-fy26-portfolio-update Additionally, a video recording of the webinar presentation will be available within 24 hours following the presentation at the Resonance Health Investor Centre homepage: https://investors.resonancehealth.com/ This announcement has been authorised for release in accordance with the delegated authority of the Board of Directors of Resonance Health Ltd. For further information: Andrew Harrison Managing Director E: andrewh@resonancehealth.com P: +61 8 9286 5300 About Resonance Health Resonance Health is an Australian healthcare technology and clinical services company. The Company has an expanding clinical trials business which both manages clinical trials in Australia and includes the site management operations of TrialsWest. The Company’s Software-as-Medical-Devices (SaMD) services are used globally by clinicians in the management of human diseases and by pharmaceutical and therapeutic companies in their clinical trials. Resonance Health has gained endorsement by leading physicians worldwide for providing high quality quantitative assessments essential in managing diseases and drug development. Page 2 Resonance Health’s dedication to scientific rigour and quality has enabled it to achieve regulatory clearances for a range of SaMDs in the USA, Europe, UK, and Australia, and to proudly carry ISO 13485 certification for the design and manufacture of medical devices. Regulatory cleared SaMD products, some of which incorporate Artificial Intelligence (AI), include: § FerriScan®, a core-lab product that provides an accurate assessment of liver iron concentration (LIC) through non-invasive MRI-based technology, for use in the assessment of individuals with iron overload conditions. Internationally recognised as the gold standard in LIC assessment. § FerriSmart®, an AI-trained, non-invasive MRI-based device for the automated real-time assessment of LIC in participants, calibrated against the global gold standard, FerriScan®. § HepaFatScan®, an MRI-based solution which provides a reliable non-invasive assessment of liver-fat in liver tissue for use in the assessment of individuals with confirmed or suspected fatty-liver-disease. § HepaFatSmart ®, an AI-trained, non-invasive device for the automated real-time multi-metric assessment of liver-fat in participants, for the assessment of individuals with confirmed or suspected fatty liver disease. § LiverSmart®, an AI-trained, non-invasive MRI-based multi-parametric device combining FerriSmart® and HepaFat-AI® into a consolidated report providing accurate assessment of LIC and liver fat. § CardiacT2*, the most widely accepted MRI method for assessing heart iron loading. Resonance Health offers a dual analysis of FerriScan® and CardiacT2*. TheCompany hasadevelopment pipelineof additional medical imaging analysisproductsandservices, including the MRI Liver Fibrosis Project, aimed at accurately assessing the presence and progression of liver fibrosis utilising non-invasive MRI analysis Stakeholders, including clinicians, participants, and shareholders, are encouraged to register their interest at www.resonancehealth.com and to follow Resonance Health on LinkedIn. A S X : R H T • I N V E S T O R P R E S E N T A T I O N Resonance Health Non-Invasive Liver Fibrosis Device & Global Medical Device Portfolio A blockbuster MRI biomarker for the era of MASH therapeutics and GLP-1 driven trials. Andrew Harrison Managing Director & CEO June 2026 ISO 13485 certified • TGA / EU MDR / FDA cleared SaMD solutions Dr Wenjie Pang Chief Scientific Officer FORWARD LOOKING STATEMENTS & DISCLAIMER This presentation has been prepared by Resonance Health Ltd (Resonance Health) and contains forward-looking statements including with respect to incomplete and ongoing R&D software-as-medical-devices (SaMD) projects. These are based on current aspirations, expectations, and/or beliefs, and are subject to uncertainties that could cause actual outcomes and results to differ materially from those described. Forward looking statements include statements about; future SaMD commercialisation, financial and operating results, regulatory submissions, possible or assumed future growth opportunities, and risks and uncertainties that may affect Resonance Health’s SaMD products and related services. Forward-looking statements are not guarantees of future performance and they involve risks, uncertainties and assumptions that are difficult to predict and are based upon assumptions as to future events that may prove inaccurate. The Non-Invasive Liver Fibrosis SaMD remains subject to various scientific and commercial hurdles including further clinical and scientific analysis and validation, and future regulatory clearances. None of these factors can be assured. Actual R&D outcomes and results may differ materially from what is expressed in any forward-looking statement in which Resonance Health expresses an aspiration, expectation or belief. There can be no assurance that the statement or expectation or belief will result or be achieved or accomplished. This presentation does not constitute or form part of an offer of securities or a solicitation of invitation to buy or apply for securities, nor may it (or any part of it) form the basis of or be relied on in connection with any contract or commitment. The information in this presentation does not account for the objectives, financial situation or individual needs of any person. Nothing in this presentation constitutes investment, legal, tax, or other advice. Potential investors should make their own decisions whether to invest in Resonance Health securities based on their own enquiries and are advised to seek appropriate independent advice. This presentation does not, and does not purport to, contain all the information prospective investors in Resonance Health would desire or require in reaching an investment decision. To the maximum extent possible by law, none of Resonance Health, their officers, directors, employees, associates, or agents, nor any other persons, accepts any liability for any loss, claim, damages, costs or expenses of whatever nature (whether foreseeable or not), including, without limitation, any liability arising from fault or negligence on the part of any of them or any other person, for any loss arising from the use of this presentation or its contents or otherwise arising in connection with it or any error or omissions in it. ASX:RHT | Liver Fibrosis Device & Medical Device Portfolio | June 2026 2 / 14 T H E O P P O R T U N I T Y A new blockbuster device — built on a profitable platform Resonance is leveraging a proven SaMD business to deliver the first MRI liver Fibrosis biomarker that directly competes with biopsy. The unmet need > 1.5B people live with chronic liver disease. Liver biopsy remains the diagnostic gold standard — but is invasive, costly, and prone to significant sampling error. Existing non-invasive methods lack accuracy & are subject to many confounding factors. Our solution Multi-parametric MRI analysis using standard MRI hardware. No contrast agent, no extra equipment, ~15-min scan. Proprietary analytics targeting biopsy-grade accuracy. Why now Approved MASH therapeutics (Resmetirom, semaglutide for MASH) plus GLP-1 trial explosion = millions of patients needing accurate non-invasive Liver Fibrosis assessment. $40B+ 2026 liver diagnostics market 58M+ New CLD cases annually $70B+ RHT total addressable market FY27/8 Targeted commercial launch ASX:RHT | Liver Fibrosis Device & Medical Device Portfolio | June 2026 2 / 14 # Market sizes - Mordor, FactMR, Research and Markets, Straits Research, plus RHT-derived estimates T H E B L O C K B U S T E R D E V I C E Multi-parametric MRI device for liver fibrosis & inflammation Development and Validation of Multiparametric MRI for Non-Invasive Measurement of Liver Fibrosis and Activity “DEVIMLA” clinical study — validating MRI as a direct alternative to liver biopsy. H O W I T W O R K S 1 Standard MRI, no extras Works on any modern MRI — no special hardware, software at the scanner, or contrast agent. 2 Multi-parametric analysis Proprietary algorithms quantify fibrosis & inflammation from native MRI signal data. 3 Confounder-resistant Designed to overcome iron, fat, body size, vessels and B1 non-uniformity that defeat competitors. 4 Whole-liver view Avoids the sampling error that plagues needle biopsy — assesses the full organ. D E V I M L A C L I N I C A L S T U D Y Development and Validation of Multiparametric MRI device for Non-Invasive Measurement of Liver Fibrosis and Activity Reference standard Percutaneous liver biopsy Patient population 68 with verified or scheduled biopsy (fully recruited) Primary endpoint Diagnostic accuracy vs significant fibrosis Secondary endpoint Quantitative monitoring; inflammation detection Duration 12–24 months (recruitment complete – analysis stage currently) PoC outcome Strong fibrosis signal; differentiates F0 from F1+ Path to FDA / CDER Biomarker Qualification ASX:RHT | Liver Fibrosis Device & Medical Device Portfolio | June 2026 3 / 14 C L I N I C A L N E E D Biopsy is the gold standard — and the problem. Why regulators, pharma sponsors, and insurers all need a better non-invasive option. L I V E R B I O P S Y Today's reference standard Invasive needle procedure with risk of bleeding & complications High cost; cannot be repeated for monitoring Sampling error — examines <0.002% of liver Inter-observer variability in histology grading Impractical for population screening Blocks GLP-1 / MASH trial recruitment / throughput R H T N O N - I N V A S I V E M R I D E V I C E In late-stage development MRI based - Painless, no needles — 15-min scan, no contrast agent Repeatable for longitudinal monitoring Whole-liver assessment — minimizes sampling error Quantitative — model-driven, reproducible output Runs on standard MRI scanners across vendors Built for FDA / CDER Biomarker Qualification 4 / 14 ASX:RHT | Liver Fibrosis Device & Medical Device Portfolio | June 2026 Provides more granular / continuous scale grading C O M P E T I T I V E L A N D S C A P E Where RHT sits among non-invasive liver fibrosis technologies Each existing modality has fundamental limitations — RHT’s device is engineered to address them simultaneously. T E C H N O L O G Y M O D A L I T Y S T R E N G T H S L I M I T A T I O N S FIB-4 / ELF Blood biomarker Cheap, widely accessible, primary care Affected by many non-fibrosis factors; poor non- advanced fibrosis accuracy FibroScan (VCTE) Ultrasound elastography Established; point-of-care; fast Fails in obesity / ascites / iron / inflammation; measures stiffness, not fibrosis itself MRE MRI elastography Best non-invasive accuracy today Requires special hardware/software on the scanner; high cost; limited access; fails in obesity / iron / inflammation; measures stiffness, not fibrosis itself LiverMultiScan (cT1) Multi-parametric MRI Vendor-agnostic; one-stop scan Measures fibro-inflammation signal indirectly; non- specific; confounded by iron, fat and others RHT Liver Fibrosis SaMD Multi-parametric MRI + analytics Vendor-agnostic, no extra hardware, confounder- resistant, full-liver In clinical validation; FDA/CDER qualification pathway underway Differentiator: RHT has the only approach combining vendor-agnostic standard MRI sequences with proprietary analytics designed from the ground up to neutralise iron, fat and signal non-uniformity — the confounders that defeat existing MRI-based methods. 5 / 14 # Competitor product sources - Imajo et al., Vali et al. (LITMUS), Bachtiar et al., NIH ClinicalTrials.gov, FDA 510(k), Loomba, FDA/CDER Guidance ASX:RHT | Liver Fibrosis Device & Medical Device Portfolio | June 2026 T O T A L A D D R E S S A B L E M A R K E T A $40B+ diagnostics market — riding three multi-billion $ tailwinds Liver disease diagnostics, MASH therapeutics and GLP-1 trial demand are converging. $40.5 BILLION 2026 global liver disease diagnostics market — TAM “How big is the market?” Imaging is 30–44% of the segment | MASLD largest at ~33% | Source: Mordor Intelligence, FactMR (2026) $8–12 BILLION Non-invasive imaging fibrosis assessment — SAM “How much of the TAM can RHT go after?” Imaging-based NILA segment growing at ~8% CAGR through 2031 | MRI-elastography fastest-growing subsegment $1–2 BILLION Initial beachhead — pharma clinical-trial imaging & MASH screening MASH pipeline + GLP-1 trials require non-invasive endpoints | Single device for global trials 58M+ new CLD cases / yr 1.7B+ people living with CLD 20%+ of global population $23B 2026 hepatic fibrosis market 6 / 14 # Market sizes - Mordor, FactMR, Research and Markets, Straits Research, plus RHT-derived estimates ASX:RHT | Liver Fibrosis Device & Medical Device Portfolio | June 2026 M A R K E T T A I L W I N D S GLP-1 boom & MASH drug wave — aligned to our endpoints Every approved therapy in this space needs non-invasive imaging to identify patients and measure response. MASH therapeutics are here Resmetirom (2024) and semaglutide (Aug 2025) are FDA-approved for MASH with liver fibrosis. Each launch requires non-invasive screening at population scale. GLP-1 trial explosion Semaglutide, tirzepatide, retatrutide, survodutide, orforglipron, CagriSema — expanding into MASH, HFpEF, CKD, OSA. Every trial needs liver fat, fibrosis, VAT/SAT & muscle quality endpoints Body-composition endpoints Regulators and sponsors now require MRI-based VAT, SAT and muscle- quality quantification alongside weight loss — to ensure quality-of- weight-loss and bone/muscle health preservation. 0 200 400 600 2022 2023 2024 2025 2026E GLP-1 / metabolic & MASH industry-sponsored trial activity — indexed (2022 = base) MASH/Liver Obesity/Metabolic Source: Company market research, IQVIA Obesity Outlook 2026, clinicaltrials.gov W H A T I T M E A N S F O R R H T ● Liver fibrosis device to launch into peak demand ● VAT/SAT & muscle quality MRI endpoints available as a central-read service ● Pharma sponsors prefer single global vendor — RHT's SaMD + CRO model wins share 7 / 14 ASX:RHT | Liver Fibrosis Device & Medical Device Portfolio | June 2026 D E V I C E P O R T F O L I O More than one device — a multi-endpoint MRI platform Liver fibrosis is the headline. The full portfolio spans fibrosis, fat, iron, inflammation, body composition and muscle quality. P R O D U C T C O N C E P T P O C L A T E D E V . C O M M E R C I A L Liver Fibrosis VAT / SAT Muscle Quality MRE central-read MRI-PDFF FerriScan Cardiac T2* Priority development — directly leverages GLP-1 / MASH tailwinds Commercial / cleared via multiple regulatory pathways Liver Fibrosis Late development — EPoC enrolment complete; validation underway. Upside not in FY26 guidance/results. VAT / SAT Central-read service commercial since FY25. Aligned with GLP-1 obesity trial demand. Muscle Quality (MRI) New endpoint — addresses sarcopenia risk in GLP-1 weight-loss trials. 8 / 14 ASX:RHT | Liver Fibrosis Device & Medical Device Portfolio | June 2026 G L P - 1 E N D P O I N T S VAT, SAT and muscle quality — already used as commercial endpoints Quantitative MRI body composition is becoming a regulatory expectation in obesity & metabolic trials. Visceral fat (VAT) Cardiometabolic risk marker Quantifies fat around organs — the cardiometabolic-driving compartment. Direct readout of GLP-1 efficacy beyond simple body weight. COMMERCIAL Central-read live FY25 Subcutaneous fat (SAT) Quality-of-weight-loss marker Distinguishes 'good' SAT loss vs problematic patterns. Required for full body-composition picture in obesity trials. COMMERCIAL Paired with VAT scan Muscle quality (MRI) Sarcopenia & safety endpoint GLP-1 weight loss can drive ~25–40% lean mass loss. Regulators and sponsors increasingly require muscle preservation evidence or muscle quality improvement. PRIORITY DEVELOPMENT Targeting trial-sponsor demand 9 / 14 ASX:RHT | Liver Fibrosis Device & Medical Device Portfolio | June 2026 T E C H N O L O G Y P L A T F O R M A scalable platform — not a single device Software-as-a-Medical-Device infrastructure already serves 400+ sites in 48 countries. Owns gold standard MRI Liver Iron device FerriScan B Y T H E N U M B E R S 400+ active MRI clinical sites worldwide 48 countries served 90,000+ analyses completed 10× target throughput uplift from automation & AI Resonance Bridge Two-way PACS integration — auto-routes jobs, strips PHI, encrypts records. First deployment underway. Zero-effort customer onboarding. Automation & AI Modern tech stack lifts SaMD capacity up to 10× at marginal cost. Platform for rapid new endpoint deployment. Regulatory moat ISO 13485 certified • TGA / EU MDR / FDA cleared SaMD solutions. Multi- year regulatory infrastructure already in place. 10 / 14 ASX:RHT | Liver Fibrosis Device & Medical Device Portfolio | June 2026 B U S I N E S S C O N T E X T Profitable platform funding the next blockbuster FY26 inflected to profitability — the new Liver Fibrosis device launches into a financially self-sustaining business. $16.0M FY26 Revenue guidance +44% pcp $2.6M FY26 guidance EBITDA 14% EBITDA margin +16pp Revenue trajectory ($M) 4 8 11 16 0 2 4 6 8 10 12 14 16 18 FY23 FY24 FY25 FY26G ~45% revenue CAGR FY23 → FY26 Three businesses funding the next device cycle SaMD: ~$5.0M FY25 segment revenue • >$10M order + bid pipeline at FY26 CRO (Resonance Clinical): $13.8M major trial in progress; $20.1M total wins since 2023 TrialsWest: 3 sites; blue-chip pharma customer base (GSK, Pfizer, Novartis, Sanofi, MSD) Project 50:28 — mid-term ambition of $50M annual revenue by end-FY28 11 / 14 ASX:RHT | Liver Fibrosis Device & Medical Device Portfolio | June 2026 D E V E L O P M E N T R O A D M A P Path to FDA biomarker qualification & commercial launch Clear milestones — each gated by clinical and regulatory rigour. Completed Initial PoC 30 subjects Fibrosis signal confirmed FY26 Extended PoC Larger cohort Multi-site MRI FY26–FY27 Validation Multi-centre validation Diverse populations FY27 Pharma Trial Deployment Pharma-sponsored trials Revenue-generating Expand clinical validation dataset FY28+ Broad Clinical Commercialisation Clinical use Important: No contribution from the Liver Fibrosis device in FY26. Planned investigational-use deployment into pharma-sponsored clinical trials during the regulatory process is expected to generate early revenue and expand the clinical validation dataset supporting future FDA regulatory submissions. — represents pure upside growth potential for FY27 and beyond. 12 / 14 FY27 Regulatory & Qualification CDER Biomarker Qualification FDA 510(k) pathway Supports future clinical adoption ASX:RHT | Liver Fibrosis Device & Medical Device Portfolio | June 2026 I N V E S T M E N T T H E S I S Why Resonance Health, why now A rare combination — profitable today, blockbuster device in trial, riding the GLP-1 wave. 01 Blockbuster device pending Liver Fibrosis SaMD addresses a clear gap in non-invasive options — and competes directly with biopsy. 02 Profitable engine 1H FY26: $1.6M EBITDA at 20% margin. Three businesses cross-selling to global pharma. 03 Direct GLP-1 exposure VAT/SAT, muscle mass, liver fat — exactly the endpoints sponsors need at scale. 04 Regulatory moat ISO 13485 + TGA/EU MDR/FDA cleared SaMD platform. Multi-year clearance work already done. 05 Global pharma reach 400+ active MRI sites, 48 countries, blue-chip customers — AstraZeneca, GSK, Pfizer, Novartis, Sanofi, MSD. 06 Significant Upside Fibrosis device, new endpoints, new TrialsWest sites, acquisitions — all incremental to FY26 numbers. 13 / 14 ASX:RHT | Liver Fibrosis Device & Medical Device Portfolio | June 2026 T H A N K Y O U Building the non-invasive standard for liver health. C O N T A C T Andrew Harrison Managing Director & CEO andrewh@resonancehealth.com +61 8 9286 5300 Forward-looking statements. Refer to the full disclaimer in ASX-released versions of the FY25 Results, 1H FY26 Results and FY26 Guidance Upgrade announcements. • ASX:RHT • www.resonancehealth.com